Human serum albumin variants determination and repartition of allotypes in 24 cases of bisalbuminemia observed in the French population


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  • Author:  Fine JM, Marneux M, North ML.

  • Weitkamp et al. (1973) using starch gel electrophoresis in three different systems of buffers (pH 5, 5.6 and 6.9) distinguish at least 24 genetically determined variants. In the European area only seven variants have been observed. The study of 24 cases of bisalbuminemia observed in the french population by acetate electrophoresis at pH 8.6 and polyacrylamide agarose gel electrophoresis at pH 8.7 and pH 6.9 can distinguish three slower variants than the normal albumin. The most frequent variant is the B type observed in 16 cases. The other types are the Pollibauer type observed in 7 cases, and the Gainsville type in one case only. The incidence of these variants can be estimated to 0.7 p. 1000 individuals.



  • Tags:  Fine  Marneux  North  Human  serum albumin  variants determinationrepartitionalloty pes24  casesbisalbuminemia observedthe  French  population  

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