Synthesis and pharmacologic study of pyridazino 4,5-b carbazoles


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    		Views: (1)   Date: (1989-10-1)   Pages: ()

  • Author:  M Robba  

  • Abstract:  Cyclization reaction of hydrazine with carbazole-2,3-methyl dicarboxylates gave 1,4-dioxo-1,2,3,4-te trahydropyridazino[4 ,5-b]carbazoles. Chlorodehydroxylatio n provided 1,4-dichloropyridazi no[4,5-b]carbazoles and nucleophilic substitution gave 1,4-dialkoxy pyridazino[4,5-b]car bazoles. These compounds were tested for cytotoxic activity against L1210 leukemia in mice.

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