Genotoxicity of bergapten and bergamot oil in Saccharomyces cerevisiae.


     Related Videos

     Related Hubpages

  •  Doc. Url:    Embed Code: 

  • PubMed  status
    (0) (0 Votes)
    Views: ()   Date: (1990-11-1)   Pages: ()
  • Author:  P Morlière  

  • Abstract:  In order to determine the genotoxic potential of bergapten (5-methoxypsoralen (5-MOP] and bergamot oil (BO), the genetic effects of 5-MOP and BO (containing equivalent amounts of 5-MOP) were studied in haploid and diploid yeast (Saccharomyces cerevisiae) using solar simulated radiation (SSR). At equal doses of SSR, equal concentrations of 5-MOP alone or 5-MOP in BO have a similar influence on survival and on the induction of cytoplasmic "petite" mutations, reverse and forward mutations, mitotic gene conversion and genetically aberrant colonies including mitotic crossing over. No reciprocity is found between SSR dose and 5-MOP concentration for cytotoxic, mutagenic and recombinogenic effects. In the presence of chemical filters (Parsol 1789, a UVA filter, and Parsol MCX, a cinnamate derivative acting as a UVB filter) considerable protection is observed against the induction of genetic effects by 5-MOP and BO containing 5-MOP in haploid and diploid cells. As indicated by the lower induction kinetics, the protection is higher than expected from the light-absorbing properties, suggesting photochemical interaction. The protection is slightly higher for BO than for 5-MOP. The induction of genetic effects by 5-MOP alone or BO containing 5-MOP is independent of oxygen. Experiments on suction blister fluids taken from patients after topical treatment with BO containing 5-MOP indicate that in comparison with water the bioavailability and thus the genotoxic effects of the compounds are decreased. Moreover, in addition to the filtering effect against the photoinduced genotoxic effects of BO, the presence of chemical filters apparently reduces the penetration of BO containing 5-MOP and provides a reduction in biological effectiveness.

     Related Documents

         Related Groups

           Related Science News

             More on Sciencestage

               Answers

                 News

                   Related on Youtube Results
            • Clemson Research Overview-Doctor Wallach on The Tom Chenault Show
              Clemson Research Overview-Doctor Wallach on The Tom Chenault Show Doctor Wallach on the Tom Chenault Show with an overview of The Clemson University studies. Youngevity® Clinical Research Study Highlights: Dietary supplemen... From: RadiantLifeTeachers Views: 291 7 ratings Time: 23:05 More in Education
            • The Clemson Univ Study and Youngevity Nutritional Products that support the body's healing!.wmv
              The Clemson Univ Study and Youngevity Nutritional Products that support the body's healing!.wmv Youngevity® Clinical Research Study Highlights: Dietary supplement safety is the most highly regarded aspect of any of the Youngevity® various products and h... From: my90forlifeplus Views: 102 1 ratings Time: 25:07 More in People & Blogs
            • Wellenfeld - genotoxicity -
              Wellenfeld - genotoxicity - The Song "genotoxicity" is taken from the CD-Album "Pandemie" www.wellenfeld.de www.mellowjet.com "Simple Colour (Album. From: dywid Views: 752 8 ratings Time: 03:52 More in Music
            • FDA Trends Impacting Hemocompatibility & Genotoxicity Testing including an ISO 10993 Update
              FDA Trends Impacting Hemocompatibility & Genotoxicity Testing including an ISO 10993 Update The Nelson Laboratories Innovation Brief at MDM East 2012 will cover recent FDA trends impacting in vitro hemocompatibility and genotoxicity testing. This pr... From: NelsonLabs Views: 156 0 ratings Time: 17:37 More in Science & Technology
            • The Future of 10993 and the Proposed ISO 10993 Changes for Hemocompatibility and Genotoxicity
              The Future of 10993 and the Proposed ISO 10993 Changes for Hemocompatibility and Genotoxicity An overview of the testing in ISO 10993-4: Selection of tests for interactions with blood and ISO 10993-3: Tests for genotoxicity, carcinogenicity and reprod... From: NelsonLabs Views: 169 0 ratings Time: 32:12 More in Science & Technology
            • Allium test shows the level of water's genotoxicity
              Allium test shows the level of water's genotoxicity An example of Allium test of water genotoxicity. Similar tests have been performed for water from Flaska bottle and showed that genotoxicity was lower by 45%... From: flaskasi Views: 945 2 ratings Time: 00:21 More in Howto & Style
            • Genotoxicity.vob
              Genotoxicity.vob NEERAJ KUMAR Ph.D Scholar. Animal Biotechnology Laboratory, Department Of Biotechnology Kurukshetra University Kurukshetra (HARYANA)-136119 Toxic effect of a... From: Neeraj Kumar Views: 211 0 ratings Time: 02:38 More in Entertainment
            • Toxicity Tests (Pt 06) - Genotoxicity
              Toxicity Tests (Pt 06) - Genotoxicity In this episode, genotoxicity will be defined, the animal tests will be examined, the non-animal tests will also be examined, and finally we will look at a f... From: CaringAboutAnimals Views: 552 0 ratings Time: 28:59 More in Science & Technology
            • Genotoxicity
              Genotoxicity From: Neeraj Kumar Views: 387 2 ratings Time: 03:08 More in Entertainment
            • Democracy Village Maria Gallastegui and Deans plight 17July 2010
              Democracy Village Maria Gallastegui and Deans plight 17July 2010 Democracy Village Camilla tells us about Dean a resident of Democracy Village who wants his right to freedom. People of peace and democracy village hold a protest to highlight the unlawful... From: radfax Views: 99 3 ratings Time: 03:33 More in News & Politics
            • Democracy Village a woman speaks out in defese of activism 17July 2010
              Democracy Village a woman speaks out in defese of activism 17July 2010 Democracy Village a woman speaks out in defese of activism 17July 2010 Let's make waves People of peace and democracy village hold a protest to highlight the unlawful wars the UK are... From: radfax Views: 61 1 ratings Time: 01:55 More in Nonprofits & Activism
            • Democracy Village Profossor Chris Knight out side the High Court
              Democracy Village Profossor Chris Knight out side the High Court Professor Chris Knight interview out side the High Court, People of peace and democracy village hold a protest to highlight the unlawful wars the UK are involved in. Much focus is raised... From: radfax Views: 62 2 ratings Time: 09:59 More in News & Politics

            •      Related on Wikipedia




























               

              Powered free by PHPmotion