Brain-specific ceramide synthesis activity: change during brain maturation and in jimpy mouse brain.
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(0) (0 Votes)Views: (5) Date: (1982-1-28) Pages: () -
Author: Y Kishimoto
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Abstract: The synthesis of ceramide from lignoceric acid was studied in normally developing rat brain and jimpy mouse brain. The developmental pattern of the synthesis of both non-hydroxy and hydroxyceramide from free lignoceric acid in a brain-specific pathway requiring NADPH and cytosolic factors was similar to the synthesis from lignoceroyl CoA and both showed increasing activity during myelination. There were no differences in non-hydroxyceramide synthesis between jimpy and normal littermate control mouse brains by both pathways. HPLC analysis showed the same non-hydroxyceramide level in both types of brains.
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