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Abstract: My deepest thanks go to my advisor, Vijay Karamcheti, whose guidance, support, and encouragement have been invaluable, and without whom this dissertation would not have been possible. Vijay always managed to keep a perfect balance between allowing me to explore new ideas and making sure that these ideas are realized in concrete research accomplishments. I would like to thank the members of my thesis proposal and dissertation defense committees: Zvi Kedem, Dennis Shasha, Robert Grimm, Ben Goldberg, and Stefan Tai, for their insightful opinions and suggestions that shaped this dissertation and helped to make it better. I?m also grateful to my colleagues at New York University for the input they provided during numerous formal and informal discussions we had,