Progeria a human-disease model of accelerated aging


     Related Videos
A clip from Papa-San's lecture on Human History sponsored by the Human's Club - YouTube
Major Threat to Human Fertility and Very Existence of Human Life on Earth
Human Trafficking- Human Rights Law and Practice
Lloyd Pye on Human Origins (6/12) (HUMAN ORIGINS LECTURE SERIES/ The Myth Of Darwinism) - ...
13. Human Rights Lecture: Section 2: Human Rights: Concept and Content: p. 17-24 - YouTube

     Related Hubpages

  •  Doc. Url:    Embed Code: 

  • PubMed  status
    (0) (0 Votes)
    Views: (1054)   Date: (13-03-09)   Pages: ()
  • Author:  Brown WT.  

  • Abstract:  Progeria: a human-disease model of accelerated aging. Brown WT. Department of Human Genetics, New York State Institute for Basic Research, Staten Island 10314. Progeria is a rare genetic disease with striking features that resemble accelerated aging. The inheritance pattern, paternal age effect, and lack of consanguinity argue that it is due to a sporadic dominant mutation. We have observed elevated levels of hyaluronic acid (HA) excretion in progeria patients. In several progeria patients we observed normal levels of growth hormone (GH) but very low levels of insulin-like growth factor I along with very high basal metabolic rates (BMRs). A trial of GH treatment was begun, which resulted in a marked increase in linear growth and a paradoxical drop in BMRs in these two patients. We hypothesize that the failure of patients with progeria to thrive may be due to a bioinactive form of GH and a lack of vasculogenesis caused by excess HA. An understanding of the progeria genetic mutation may define a key gene with a major effect on normal aging. PMID: 1590260 [PubMed - indexed for MEDLINE]

     Related Documents

         Related Groups

           Related Science News

             More on Sciencestage

               Answers

                 News

                   Related on Youtube Results
            • Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri
              Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri Thanks to a new drug treatment, Lindsay Ratcliffe grew 6 cm and added 2.2 lbs.; watch Sat. 8. From: world news Views: 0 0 ratings Time: 01:31 More in News & Politics
            • Xyriel Manabat a Progeria-striken teenager in MMK Dec 20 2014
              Xyriel Manabat a Progeria-striken teenager in MMK Dec 20 2014 Xyriel Manabat on MMK December 20 2014 Xyriel Manabat portrays the role of a progeria-striken teenager named Rochelle,despite her ailment, lives a normal life in Maalaala Mo Kaya Saturday... From: Hot & Trending Views: 12 0 ratings Time: 01:09 More in People & Blogs
            • The Triumphant Story of Sam Berns, Progeria and Mat
              The Triumphant Story of Sam Berns, Progeria and Mat Mother of teenager with progeria discovers genetic mutation, and works to develop a drug. From: world news Views: 0 0 ratings Time: 02:53 More in News & Politics
            • Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri
              Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri Thanks to a new drug treatment, Lindsay Ratcliffe grew 6 cm and added 2.2 lbs.; watch Sat. 8. From: news 01 Views: 0 0 ratings Time: 01:31 More in News & Politics
            • The Triumphant Story of Sam Berns, Progeria and Mat
              The Triumphant Story of Sam Berns, Progeria and Mat Mother of teenager with progeria discovers genetic mutation, and works to develop a drug. From: news 01 Views: 1 0 ratings Time: 02:53 More in News & Politics
            • Project for Awesome 2014: Progeria Research Foundation
              Project for Awesome 2014: Progeria Research Foundation Our video is in support of the Progeria Research Foundation. www.progeriaresearch.org www.projectforawesome.com. From: Jessica Gold Views: 218 9 ratings Time: 02:40 More in Nonprofits & Activism
            • Progeria new part 1
              Progeria new part 1 Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool... From: Heather Crawford Views: 3 0 ratings Time: 05:06 More in Film & Animation
            • Progeria part 2
              Progeria part 2 Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool... From: Heather Crawford Views: 6 0 ratings Time: 03:40 More in Film & Animation
            • Progeria part 1
              Progeria part 1 Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool... From: Heather Crawford Views: 7 0 ratings Time: 05:06 More in Film & Animation
            • Progeria part 1
              Progeria part 1 Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool... From: Heather Crawford Views: 2 0 ratings Time: 05:06 More in Film & Animation
            • The Power of Sports to Raise Awareness of Orphan Disease - The Progeria Story
              The Power of Sports to Raise Awareness of Orphan Disease - The Progeria Story Sports and other community or celebrity events can bring attention to a variety of causes, including rare diseases. In this interview with Audrey Gordon, Pre... From: Rare Disease Report Views: 17 0 ratings Time: 02:15 More in Science & Technology
            • Opie & Anthony: Opie Saw The Progeria Documentary (10/28/13)
              Opie & Anthony: Opie Saw The Progeria Documentary (10/28/13) 2) Lady Di is now on Twitter: @dianaorbani777 ----- To listen to The Opie & Anthony Show live, five days a week between 6am-10am ET on XM 103 / Sirius 206, s... From: Opie And Jim Norton Views: 0 0 ratings Time: 19:30 More in Comedy
            • Opie & Anthony John Spano and Progeria Documentaries 10 24 13
              Opie & Anthony John Spano and Progeria Documentaries 10 24 13 From: Opie And Jim Norton Views: 0 0 ratings Time: 39:25 More in Comedy
            • Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri
              Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri Thanks to a new drug treatment, Lindsay Ratcliffe grew 6 cm and added 2.2 lbs.; watch Sat. 8. From: World News Views: 1 0 ratings Time: 01:31 More in News & Politics
            • The Triumphant Story of Sam Berns, Progeria and Mat
              The Triumphant Story of Sam Berns, Progeria and Mat Mother of teenager with progeria discovers genetic mutation, and works to develop a drug. From: World News Views: 0 0 ratings Time: 02:53 More in News & Politics
            • NIÑOS ESPECIALES PROGERIA
              NIÑOS ESPECIALES PROGERIA Descripción ENSAYO FOTOGRAFICO POETICO. From: yzabel del angel Views: 3 0 ratings Time: 02:25 More in People & Blogs
            • Progeria
              Progeria This video is about Progeria. From: Morgan VanSciver Views: 5 0 ratings Time: 04:00 More in Film & Animation
            • Progeria Infancia Interrumpida
              Progeria Infancia Interrumpida 1- Terror 2- Inanición 3- Una guerra mas 4- No os Importa 5- Niños del pasado 6- La dama blanca 7- Verdugos 8- Virus 9- El coche fantástico 10- El instrument... From: Javi Progeria Views: 5 0 ratings Time: 38:44 More in Music
            • Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri
              Progeria Update: Hope Grows for Girl With Rare Rapid-Aging Disease Progeri Thanks to a new drug treatment, Lindsay Ratcliffe grew 6 cm and added 2.2 lbs.; watch Sat. 8. From: ABС world news Views: 0 0 ratings Time: 01:31 More in News & Politics
            • Progeria Jesper Video
              Progeria Jesper Video From: Frederik Fog Views: 14 0 ratings Time: 02:20 More in People & Blogs
            • Progeria Audio
              Progeria Audio From: Briseyda Gonzalez Views: 14 0 ratings Time: 07:36 More in People & Blogs
            • Progeria
              Progeria I am sorry. The audio seemed to disappear when I was editing it. Here is a fixed link: https://www.youtube.com/watch?v=qjRMqQHSVTM&list=UUcgdAv_rQbpMPxqWyLO5Cxw. From: Briseyda Gonzalez Views: 26 0 ratings Time: 07:12 More in People & Blogs
            • The Triumphant Story of Sam Berns, Progeria and Mat
              The Triumphant Story of Sam Berns, Progeria and Mat Mother of teenager with progeria discovers genetic mutation, and works to develop a drug. From: ABС world news Views: 1 0 ratings Time: 02:53 More in News & Politics
            • El Malilla ( Progeria épica )
              El Malilla ( Progeria épica ) Les dejamos nuestro 1er cortometraje cabros :') esperamos que les guste ( es con mucho amor ), además contamos en que se suscriban, compartan y likes akjakja... From: NedaRhen Views: 130 7 ratings Time: 19:47 More in Film & Animation
            • Progeria Craft #3 (Fuego qlo-.-) - Minecraft - Progeriosos Gamer
              Progeria Craft #3 (Fuego qlo-.-) - Minecraft - Progeriosos Gamer Visita http://paypal-chile.webnode.cl/ para encontrar increíbles ofertas! Si te gusto aplicale al like y suscribete plis*: From: Progeriosos Gamer Views: 44 17 ratings Time: 01:18:18 More in Gaming

            •      Related on Wikipedia




























               

              Powered free by PHPmotion